Anti-PTK7 Monoclonal Antibodies Inhibit Angiogenesis by Suppressing PTK7 Function

Anti-PTK7 Monoclonal Antibodies Inhibit Angiogenesis by Suppressing PTK7 Function

PTK7, a catalytically defective receptor protein tyrosine kinase, promotes angiogenesis by activating KDR through direct interaction and induction of KDR oligomerization. This study developed anti-PTK7 monoclonal antibodies (mAbs) to regulate angiogenesis by inhibiting PTK7 function. The effect of a...

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Bibliographic Details
Main Authors: Si Won Oh, Won-Sik Shin, Seung-Taek Lee
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
PTK7
receptor protein tyrosine kinase
angiogenesis
neutralizing antibody
KDR
Online Access:https://www.mdpi.com/2072-6694/14/18/4463

Internet

https://www.mdpi.com/2072-6694/14/18/4463

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