Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells

The cellular effects of hydrogen sulfide (H2S) signaling may be partially mediated by the formation of alkyl persulfides from thiols, such as glutathione and protein cysteine residues. Persulfides are potent nucleophiles and reductants and therefore potentially an important endogenous antioxidant or...

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Bibliographic Details
Main Authors: Christopher H. Switzer, Sebastian Guttzeit, Thomas R. Eykyn, Philip Eaton
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Redox Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721003153