Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network

Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network

Innovations in metazoan development arise from evolutionary modification of gene regulatory networks (GRNs). We report widespread cryptic variation in the requirement for two key regulatory inputs, SKN-1/Nrf2 and MOM-2/Wnt, into the C. elegans endoderm GRN. While some natural isolates show a nearly...

Full description

Bibliographic Details
Main Authors: Yamila N Torres Cleuren, Chee Kiang Ewe, Kyle C Chipman, Emily R Mears, Cricket G Wood, Coco Emma Alma Al-Alami, Melissa R Alcorn, Thomas L Turner, Pradeep M Joshi, Russell G Snell, Joel H Rothman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
SKN-1
GWAS
development
GRN
cryptic variation
genotype-by-sequencing
Online Access:https://elifesciences.org/articles/48220

Internet

https://elifesciences.org/articles/48220

Similar Items