Assessing the Effects of VEGF Releasing Microspheres on the Angiogenic and Foreign Body Response to a 3D Printed Silicone-Based Macroencapsulation Device

Assessing the Effects of VEGF Releasing Microspheres on the Angiogenic and Foreign Body Response to a 3D Printed Silicone-Based Macroencapsulation Device

Macroencapsulation systems have been developed to improve islet cell transplantation but can induce a foreign body response (FBR). The development of neovascularization adjacent to the device is vital for the survival of encapsulated islets and is a limitation for long-term device success. Previousl...

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Bibliographic Details
Main Authors: Ruth E. Levey, Fergal B. Coulter, Karina C. Scheiner, Stefano Deotti, Scott T. Robinson, Liam McDonough, Thanh T. Nguyen, Rob Steendam, Mark Canney, Robert Wylie, Liam P. Burke, Eimear B. Dolan, Peter Dockery, Helena M. Kelly, Giulio Ghersi, Wim E. Hennink, Robbert J. Kok, Eoin O’Cearbhaill, Garry P. Duffy
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
diabetes
prevascularization
drug delivery
VEGF
medical device
multi-scale porosity
Online Access:https://www.mdpi.com/1999-4923/13/12/2077

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https://www.mdpi.com/1999-4923/13/12/2077

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