IL-38 Gene Deletion Worsens Murine Colitis

IL-38 Gene Deletion Worsens Murine Colitis

IL-38 is a recently discovered cytokine and member of the IL-1 Family. In the IL-1 Family, IL-38 is unique because the cytokine is primarily a B lymphocyte product and functions to suppress inflammation. Studies in humans with inflammatory bowel disease (IBD) suggest that IL-38 may be protective for...

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Bibliographic Details
Main Authors: Dennis M. de Graaf, Ruth X. Wang, Jesús Amo-Aparicio, J. Scott Lee, Alexander S. Dowdell, Isak W. Tengesdal, Carlo Marchetti, Sean P. Colgan, Leo A. B. Joosten, Charles A. Dinarello
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
IL-38
NLRP3
IL-1α
IL-1β
colitis
IBD – inflammatory bowel diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.840719/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.840719/full

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