Metabolic approaches to rescue antitumor Vγ9Vδ2 T-cell functions in myeloma

Vγ9Vδ2 T cells are immune effector cells very well-suited for immunotherapy, but clinical results have been disappointing in multiple myeloma (MM) and other cancers. We have shown that Vγ9Vδ2 T cells are victimized prematurely by the immune suppressive tumor microenvironment (TME) established by mye...

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Bibliographic Details
Main Authors: Barbara Castella, Chiara Riganti, Massimo Massaia
Format: Article
Language:English
Published: IMR Press 2020-01-01
Series:Frontiers in Bioscience-Landmark
Subjects:
Online Access:https://www.imrpress.com/journal/FBL/25/1/10.2741/4795