A Novel Cyclic Pentadepsipeptide, <i>N</i>-Methylsansalvamide, Suppresses Angiogenic Responses and Exhibits Antitumor Efficacy against Bladder Cancer

A Novel Cyclic Pentadepsipeptide, <i>N</i>-Methylsansalvamide, Suppresses Angiogenic Responses and Exhibits Antitumor Efficacy against Bladder Cancer

Here, we explored the anti-tumor efficacy of a cyclic pentadepsipeptide, <i>N</i>-methylsansalvamide (MSSV), in bladder cancer. MSSV inhibited the proliferation of both bladder cancer 5637 and T24 cells, which was attributed to the G1-phase cell cycle arrest, apoptosis induction, and alt...

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Bibliographic Details
Main Authors: Jun-Hui Song, Juhee Park, Sung Lyea Park, Byungdoo Hwang, Wun-Jae Kim, Chan Lee, Sung-Kwon Moon
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
MSSV
bladder cancer
anti-tumor efficacy
anti-angiogenesis
single oral dose of acute toxicity
Online Access:https://www.mdpi.com/2072-6694/13/2/191

Internet

https://www.mdpi.com/2072-6694/13/2/191

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