Dual VEGFA/BRAF targeting boosts PD‐1 blockade in melanoma through GM‐CSF‐mediated infiltration of M1 macrophages

Dual VEGFA/BRAF targeting boosts PD‐1 blockade in melanoma through GM‐CSF‐mediated infiltration of M1 macrophages

The introduction of targeted therapies represented one of the most significant advances in the treatment of BRAFV600E melanoma. However, the onset of acquired resistance remains a challenge. Previously, we showed in mouse xenografts that vascular endothelial growth factor (VEGFA) removal enhanced th...

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Bibliographic Details
Main Authors: Valentina Comunanza, Chiara Gigliotti, Simona Lamba, Gabriella Doronzo, Edoardo Vallariello, Valentina Martin, Claudio Isella, Enzo Medico, Alberto Bardelli, Dario Sangiolo, Federica Di Nicolantonio, Federico Bussolino
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Molecular Oncology
Subjects:
BRAF
M1‐macrophage
melanoma
VEGFA
Online Access:https://doi.org/10.1002/1878-0261.13450

Internet

https://doi.org/10.1002/1878-0261.13450

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