The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process

The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process

Parkinson’s Disease (PD) is a progressive neurodegenerative disease characterized by the presence of proteinaceous aggregates of αSynuclein (αSyn) in the dopaminergic neurons. Chaperones are key components of the proteostasis network that are able to counteract αSyn’s aggregation, as well as its tox...

Full description

Bibliographic Details
Main Authors: Chiara Lenzi, Ileana Ramazzina, Isabella Russo, Alice Filippini, Saverio Bettuzzi, Federica Rizzi
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
clusterin
αSynuclein
proteostasis
chaperone
protein aggregation
heat shock protein
Online Access:https://www.mdpi.com/1422-0067/21/19/7181

Internet

https://www.mdpi.com/1422-0067/21/19/7181

Similar Items