Role of Endocytosis Proteins in Gefitinib-Mediated EGFR Internalisation in Glioma Cells

Role of Endocytosis Proteins in Gefitinib-Mediated EGFR Internalisation in Glioma Cells

EGFR (epidermal growth factor receptor), a member of the ErbB tyrosine kinase receptor family, is a clinical therapeutic target in numerous solid tumours. EGFR overexpression in glioblastoma (GBM) drives cell invasion and tumour progression. However, clinical trials were disappointing, and a molecul...

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Bibliographic Details
Main Authors: Elisabete Cruz Da Silva, Laurence Choulier, Jessica Thevenard-Devy, Christophe Schneider, Philippe Carl, Philippe Rondé, Stéphane Dedieu, Maxime Lehmann
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
glioblastoma
cell invasion
membrane trafficking
tyrosine kinase inhibitors
Online Access:https://www.mdpi.com/2073-4409/10/11/3258

Internet

https://www.mdpi.com/2073-4409/10/11/3258

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