Heparan Sulfates Regulate Axonal Excitability and Context Generalization through Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II

Heparan Sulfates Regulate Axonal Excitability and Context Generalization through Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II

Our previous studies demonstrated that enzymatic removal of highly sulfated heparan sulfates with heparinase 1 impaired axonal excitability and reduced expression of ankyrin G at the axon initial segments in the CA1 region of the hippocampus ex vivo, impaired context discrimination in vivo, and incr...

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Bibliographic Details
Main Authors: Inseon Song, Tatiana Kuznetsova, David Baidoe-Ansah, Hadi Mirzapourdelavar, Oleg Senkov, Hussam Hayani, Andrey Mironov, Rahul Kaushik, Michael Druzin, Staffan Johansson, Alexander Dityatev
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
extracellular matrix
synaptic plasticity
context discrimination
axon initial segment
axonal excitability
ankyrin G
Online Access:https://www.mdpi.com/2073-4409/12/5/744

Internet

https://www.mdpi.com/2073-4409/12/5/744

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