Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity.

Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity.

The androgen receptor (AR) plays a central role in prostate cancer. Development of castration resistant prostate cancer (CRPC) requires androgen-independent activation of AR, which involves its large N-terminal domain (NTD) and entails extensive epigenetic changes depending in part on histone lysine...

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Bibliographic Details
Main Authors: Carlos M Roggero, Victoria Esser, Lingling Duan, Allyson M Rice, Shihong Ma, Ganesh V Raj, Michael K Rosen, Zhi-Ping Liu, Josep Rizo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0258876&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0258876&type=printable

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