IL-13/IL-13RA2 signaling promotes colorectal cancer stem cell tumorigenesis by inducing ubiquitinated degradation of p53

IL-13/IL-13RA2 signaling promotes colorectal cancer stem cell tumorigenesis by inducing ubiquitinated degradation of p53

Cancer stem cells (CSCs) are considered tumor-initiating cells and the main drivers of disease progression. Targeting these rare cancer cells, however, remains challenging with respect to therapeutic benefit. Here, we report the up-regulation of IL-13RA2 expression in colorectal cancer (CRC) tissues...

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Bibliographic Details
Main Authors: Baoyu He, Jing Liang, Qianqian Qin, Yuqin Zhang, Shuo Shi, Jinghe Cao, Zhixin Zhang, Qingli Bie, Rou Zhao, Li Wei, Baogui Zhang, Bin Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-01-01
Series:Genes and Diseases
Subjects:
Autophagy
Colorectal cancer stem cells
IL-13/IL-13RA2 signaling
p53
Ubiquitinated degradation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304223000521

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http://www.sciencedirect.com/science/article/pii/S2352304223000521

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