Subordinate Effect of -21M HLA-B Dimorphism on NK Cell Repertoire Diversity and Function in HIV-1 Infected Individuals of African Origin

Subordinate Effect of -21M HLA-B Dimorphism on NK Cell Repertoire Diversity and Function in HIV-1 Infected Individuals of African Origin

Natural Killer (NK) cells play an important role in antiviral defense and their potent effector function identifies them as key candidates for immunotherapeutic interventions in chronic viral infections. Their remarkable functional agility is achieved by virtue of a wide array of germline-encoded in...

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Bibliographic Details
Main Authors: Elia Moreno Cubero, Ane Ogbe, Isabela Pedroza-Pacheco, Myron S. Cohen, Barton F. Haynes, Persephone Borrow, Dimitra Peppa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
Natural Killer cells
HIV-1
HCMV
HLA-B
HLA-C
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00156/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00156/full

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