SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury

SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury

Abstract Background Microglia is the major contributor of post-stroke neuroinflammation cascade and the crucial cellular target for the treatment of ischemic stroke. Currently, the endogenous mechanism underlying microglial activation following ischemic stroke remains elusive. Serglycin (SRGN) is a...

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Bibliographic Details
Main Authors: Yi Qian, Lixuan Yang, Jian Chen, Chao Zhou, Ningning Zong, Yang Geng, Shengnan Xia, Haiyan Yang, Xinyu Bao, Yan Chen, Yun Xu
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Neuroinflammation
Subjects:
Ischemic stroke
Neuroinflammation
Microglia
Serglycin
CD44
Online Access:https://doi.org/10.1186/s12974-024-03026-6

Internet

https://doi.org/10.1186/s12974-024-03026-6

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