Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications

Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications

The coronavirus disease 2019 (COVID-19) pandemic has led to worldwide efforts to understand the biological traits of the newly identified human coronavirus (HCoV-19) virus. In this mass spectrometry (MS)-based study, we reveal that out of 21 possible glycosites in the HCoV-19 spike protein (S protei...

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Bibliographic Details
Main Authors: Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Engineering
Subjects:
N-glycosylation
COVID-19
Spike protein
hACE2
Structure
Online Access:http://www.sciencedirect.com/science/article/pii/S2095809920302344

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http://www.sciencedirect.com/science/article/pii/S2095809920302344

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