Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner

Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner

Mitochondrial dysfunction and oxidative injury, which contribute to worsening of neurological deficits and poor clinical outcomes, are hallmarks of secondary brain injury after TBI. Adiponectin (APN), beyond its well-established regulatory effects on metabolism, is also essential for maintaining nor...

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Bibliographic Details
Main Authors: Shenghao Zhang, Xun Wu, Jin Wang, Yingwu Shi, Qing Hu, Wenxing Cui, Hao Bai, Jinpeng Zhou, Yong Du, Liying Han, Leiyang Li, Dayun Feng, Shunnan Ge, Yan Qu
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Redox Biology
Subjects:
TBI
APN
SIRT3
Oxidative stress
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001628

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http://www.sciencedirect.com/science/article/pii/S2213231722001628

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