Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer

Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer

Summary: Inactivation of Capicua (CIC) or upregulation of yes-associated protein 1, YAP1, leads to broad RAS-RAF-MEK-ERK inhibitor resistance and tumor progression in multiple human cancers. Despite these shared malignant phenotypes, it remains unclear whether CIC and YAP1 are mechanistically linked...

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Bibliographic Details
Main Authors: Ji Won Kim, Cuyler Luck, Wei Wu, Rovingaile Kriska Ponce, Yone Kawe Lin, Nehal Gupta, Ross A. Okimoto
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722012840

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http://www.sciencedirect.com/science/article/pii/S2211124722012840

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