Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

<p>Abstract</p> <p>Background</p> <p>The form(s) of amyloid-β peptide (Aβ) associated with the pathology characteristic of Alzheimer's disease (AD) remains unclear. In particular, the neurotoxicity of intraneuronal Aβ accumulation is an issue of considerable contro...

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Main Authors: Youmans Katherine L, Tai Leon M, Kanekiyo Takahisa, Stine W Blaine, Michon Sara-Claude, Nwabuisi-Heath Evelyn, Manelli Arlene M, Fu Yifan, Riordan Sean, Eimer William A, Binder Lester, Bu Guojun, Yu Chunjiang, Hartley Dean M, LaDu Mary Jo
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Molecular Neurodegeneration
Subjects:
Intraneuronal
Aβ
APP
MOAB-2
3xTg
5xFAD
Antibody
Alzheimer's disease
Online Access:http://www.molecularneurodegeneration.com/content/7/1/8

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