Enhancing arginase 2 expression using target site blockers as a strategy to modulate macrophage phenotype

Enhancing arginase 2 expression using target site blockers as a strategy to modulate macrophage phenotype

Macrophages are plastic cells playing a crucial role in innate immunity. While fundamental in responding to infections, when persistently maintained in a pro-inflammatory state they can initiate and sustain inflammatory diseases. Therefore, a strategy that reprograms pro-inflammatory macrophages tow...

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Bibliographic Details
Main Authors: Chiara De Santi, Frances K. Nally, Remsha Afzal, Conor P. Duffy, Stephen Fitzsimons, Stephanie L. Annett, Tracy Robson, Jennifer K. Dowling, Sally-Ann Cryan, Claire E. McCoy
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: non-coding RNAs
microRNAs
macrophages
target site blocker
arginase 2
miR-155
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122002001

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http://www.sciencedirect.com/science/article/pii/S2162253122002001

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