Immune desert in MMR-deficient tumors predicts poor responsiveness of immune checkpoint inhibition

Immune desert in MMR-deficient tumors predicts poor responsiveness of immune checkpoint inhibition

BackgroundAlthough many efforts have been devoted to identify biomarkers to predict the responsiveness of immune checkpoint inhibitors, including expression of programmed death-ligand 1 (PD-L1) and major histocompatibility complex (MHC) I, microsatellite instability (MSI), mismatch repair (MMR) defe...

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Bibliographic Details
Main Authors: Guoxing Zheng, Yingsi Lu, Zheng Yang, Hong Chen, Qian Liang, Qingqing Zhu, Yan Li, Xing Xiao, Zhuzhen He, Yifan Zhu, Bo Li, Leilei Huang, Nan Dong, Shuang Hu, Yihang Pan, Changhua Zhang, Chengming Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
mismatch repair
tumor immune signatures
somatic mutation
immunotherapy responsiveness prediction
tertiary lymphoid structures
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1142862/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1142862/full

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