Blockage of VEGF function by bevacizumab alleviates early-stage cerebrovascular dysfunction and improves cognitive function in a mouse model of Alzheimer’s disease

Blockage of VEGF function by bevacizumab alleviates early-stage cerebrovascular dysfunction and improves cognitive function in a mouse model of Alzheimer’s disease

Abstract Background Alzheimer's disease (AD) is a neurodegenerative disorder and the predominant type of dementia worldwide. It is characterized by the progressive and irreversible decline of cognitive functions. In addition to the pathological beta-amyloid (Aβ) deposition, glial activation, an...

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Bibliographic Details
Main Authors: Min Zhang, Zhan Zhang, Honghong Li, Yuting Xia, Mengdan Xing, Chuan Xiao, Wenbao Cai, Lulu Bu, Yi Li, Tae-Eun Park, Yamei Tang, Xiaojing Ye, Wei-Jye Lin
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
Bevacizumab
Vascular endothelial growth factor
Cerebrovascular function
Online Access:https://doi.org/10.1186/s40035-023-00388-4

Internet

https://doi.org/10.1186/s40035-023-00388-4

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