IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction

IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction

Excessive and chronic inflammation post myocardial infarction (MI) causes cardiac fibrosis and progressive ventricular remodeling, which leads to heart failure. We previously found high levels of IL-27 in the heart and serum until day 14 in murine cardiac ischemia‒reperfusion injury models. However,...

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Bibliographic Details
Main Authors: Xiaoxue Ma, Qingshu Meng, Shiyu Gong, Shanshan Shi, Xiaoting Liang, Fang Lin, Li Gong, Xuan Liu, Yinzhen Li, Mimi Li, Lu Wei, Wei Han, Leng Gao, Zhongmin Liu, Xiaohui Zhou
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Heliyon
Subjects:
IL-27
Fibroblast
Myocardial infarction
Inflammation
Ventricular remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023043074

Internet

http://www.sciencedirect.com/science/article/pii/S2405844023043074

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