IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction
Excessive and chronic inflammation post myocardial infarction (MI) causes cardiac fibrosis and progressive ventricular remodeling, which leads to heart failure. We previously found high levels of IL-27 in the heart and serum until day 14 in murine cardiac ischemia‒reperfusion injury models. However,...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023043074 |
| _version_ | 1797798026284105728 |
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| author | Xiaoxue Ma Qingshu Meng Shiyu Gong Shanshan Shi Xiaoting Liang Fang Lin Li Gong Xuan Liu Yinzhen Li Mimi Li Lu Wei Wei Han Leng Gao Zhongmin Liu Xiaohui Zhou |
| author_facet | Xiaoxue Ma Qingshu Meng Shiyu Gong Shanshan Shi Xiaoting Liang Fang Lin Li Gong Xuan Liu Yinzhen Li Mimi Li Lu Wei Wei Han Leng Gao Zhongmin Liu Xiaohui Zhou |
| author_sort | Xiaoxue Ma |
| collection | DOAJ |
| description | Excessive and chronic inflammation post myocardial infarction (MI) causes cardiac fibrosis and progressive ventricular remodeling, which leads to heart failure. We previously found high levels of IL-27 in the heart and serum until day 14 in murine cardiac ischemia‒reperfusion injury models. However, whether IL-27 is involved in chronic inflammation-mediated ventricular remodeling remains unclear. In the present study, we found that MI triggered high IL-27 expression in murine cardiac macrophages. The increased expression of IL-27 in serum is correlated with cardiac dysfunction and aggravated fibrosis after MI. Furthermore, the addition of IL-27 significantly activated the JAK/STAT signaling pathway in cardiac fibroblasts (CFs). Meanwhile, IL-27 treatment promoted the proliferation, migration and extracellular matrix (ECM) production of CFs induced by angiotensin II (Ang II). Collectively, high levels of IL-27 mainly produced by cardiac macrophages post MI contribute to the activation of CFs and aggravate cardiac fibrosis. |
| first_indexed | 2024-03-13T03:57:14Z |
| format | Article |
| id | doaj.art-ae431cb010404df29ee738634cc5db98 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T03:57:14Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-ae431cb010404df29ee738634cc5db982023-06-22T05:04:22ZengElsevierHeliyon2405-84402023-06-0196e17099IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarctionXiaoxue Ma0Qingshu Meng1Shiyu Gong2Shanshan Shi3Xiaoting Liang4Fang Lin5Li Gong6Xuan Liu7Yinzhen Li8Mimi Li9Lu Wei10Wei Han11Leng Gao12Zhongmin Liu13Xiaohui Zhou14Shanghai East Hospital, Jinzhou Medical University, Jinzhou, 121000, China; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Shanghai Heart Failure Research Center, Shanghai, 200120, ChinaDepartment of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Shanghai Heart Failure Research Center, Shanghai, 200120, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Shanghai Heart Failure Research Center, Shanghai, 200120, ChinaShanghai East Hospital, Jinzhou Medical University, Jinzhou, 121000, China; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Shanghai Heart Failure Research Center, Shanghai, 200120, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Shanghai Heart Failure Research Center, Shanghai, 200120, ChinaDepartment of Heart Failure, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, ChinaTranslational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, PR ChinaShanghai Heart Failure Research Center, Shanghai, 200120, China; Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200120, China; Corresponding author. Research Center for Translational Medicine, Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine 150 Jimo Rd, Pudong, Shanghai, 200120, China.Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Shanghai Heart Failure Research Center, Shanghai, 200120, China; Corresponding author. Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine 150 Jimo Rd, Pudong, Shanghai, 200120, ORCID, China.Excessive and chronic inflammation post myocardial infarction (MI) causes cardiac fibrosis and progressive ventricular remodeling, which leads to heart failure. We previously found high levels of IL-27 in the heart and serum until day 14 in murine cardiac ischemia‒reperfusion injury models. However, whether IL-27 is involved in chronic inflammation-mediated ventricular remodeling remains unclear. In the present study, we found that MI triggered high IL-27 expression in murine cardiac macrophages. The increased expression of IL-27 in serum is correlated with cardiac dysfunction and aggravated fibrosis after MI. Furthermore, the addition of IL-27 significantly activated the JAK/STAT signaling pathway in cardiac fibroblasts (CFs). Meanwhile, IL-27 treatment promoted the proliferation, migration and extracellular matrix (ECM) production of CFs induced by angiotensin II (Ang II). Collectively, high levels of IL-27 mainly produced by cardiac macrophages post MI contribute to the activation of CFs and aggravate cardiac fibrosis.http://www.sciencedirect.com/science/article/pii/S2405844023043074IL-27FibroblastMyocardial infarctionInflammationVentricular remodeling |
| spellingShingle | Xiaoxue Ma Qingshu Meng Shiyu Gong Shanshan Shi Xiaoting Liang Fang Lin Li Gong Xuan Liu Yinzhen Li Mimi Li Lu Wei Wei Han Leng Gao Zhongmin Liu Xiaohui Zhou IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction Heliyon IL-27 Fibroblast Myocardial infarction Inflammation Ventricular remodeling |
| title | IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction |
| title_full | IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction |
| title_fullStr | IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction |
| title_full_unstemmed | IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction |
| title_short | IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction |
| title_sort | il 27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction |
| topic | IL-27 Fibroblast Myocardial infarction Inflammation Ventricular remodeling |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023043074 |
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