Epigenetic Changes in the CRH Gene are Related to Severity of Suicide Attempt and a General Psychiatric Risk Score in Adolescents

Epigenetic Changes in the CRH Gene are Related to Severity of Suicide Attempt and a General Psychiatric Risk Score in Adolescents

The aim of this study, comprising 88 suicide attempters, was to identify hypothalamic-pituitary-adrenal (HPA) -axis coupled CpG-sites showing methylation shifts linked to severity of the suicide attempt. Candidate methylation loci were further investigated as risk loci for a general psychiatric risk...

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Bibliographic Details
Main Authors: Jussi Jokinen, Adrian E. Boström, Ali Dadfar, Diana M. Ciuculete, Andreas Chatzittofis, Marie Åsberg, Helgi B. Schiöth
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:EBioMedicine
Subjects:
Suicide
Suicide attempt
HPA axis
CRH gene
Epigenetics
Methylation
Adolescent depression
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417304991

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http://www.sciencedirect.com/science/article/pii/S2352396417304991

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