A rare human variant that disrupts GPR10 signalling causes weight gain in mice

A rare human variant that disrupts GPR10 signalling causes weight gain in mice

The brain-expressed receptor GPR10 is involved in energy homeostasis in mice. Here the authors identify rare loss of function variants in GPR10 in people with severe obesity and showed that one of these variants causes obesity when modelled in mice, suggesting that future studies could explore GPR10...

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Bibliographic Details
Main Authors: Fleur Talbot, Claire H. Feetham, Jacek Mokrosiński, Katherine Lawler, Julia M. Keogh, Elana Henning, Edson Mendes de Oliveira, Vikram Ayinampudi, Sadia Saeed, Amélie Bonnefond, Mohammed Arslan, Giles S. H. Yeo, Philippe Froguel, David A. Bechtold, Antony Adamson, Neil Humphreys, Inês Barroso, Simon M. Luckman, I. Sadaf Farooqi
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36966-3

Internet

https://doi.org/10.1038/s41467-023-36966-3

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