Enhanced Synaptic Potentiation in Transgenic Mice Expressing presenilin 1 Familial Alzheimer's Disease Mutation Is Normalized with a Benzodiazepine

Enhanced Synaptic Potentiation in Transgenic Mice Expressing presenilin 1 Familial Alzheimer's Disease Mutation Is Normalized with a Benzodiazepine

Mutations in presenilin 1 (PS1) are the most common causes of familial Alzheimer's disease (FAD). We examined synaptic physiology in hippocampal brain slices of transgenic mice expressing the FAD-linked PS1 deletion of exon 9 variant. Basal excitatory transmission and paired-pulse facilitation...

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Bibliographic Details
Main Authors: Shahid H. Zaman, Angèle Parent, Aaron Laskey, Michael K. Lee, David R. Borchelt, Sangram S. Sisodia, Roberto Malinow
Format: Article
Language:English
Published: Elsevier 2000-02-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996199902711

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http://www.sciencedirect.com/science/article/pii/S0969996199902711

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