Selective Role of the Catalytic PI3K Subunit p110β in Impaired Higher Order Cognition in Fragile X Syndrome

Selective Role of the Catalytic PI3K Subunit p110β in Impaired Higher Order Cognition in Fragile X Syndrome

Distinct isoforms of the PI3K catalytic subunit have specialized functions in the brain, but their role in cognition is unknown. Here, we show that the catalytic subunit p110β plays an important role in prefrontal cortex (PFC)-dependent cognitive defects in mouse models of Fragile X syndrome (FXS),...

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Bibliographic Details
Main Authors: Christina Gross, Nisha Raj, Gemma Molinaro, Amanda G. Allen, Alonzo J. Whyte, Jay R. Gibson, Kimberly M. Huber, Shannon L. Gourley, Gary J. Bassell
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715003563

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http://www.sciencedirect.com/science/article/pii/S2211124715003563

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