Mitochondrial Respiration Defects in Single-Ventricle Congenital Heart Disease

Mitochondrial Respiration Defects in Single-Ventricle Congenital Heart Disease

Background: Congenital heart disease (CHD) with single-ventricle (SV) physiology is now survivable with a three-stage surgical course ending with Fontan palliation. However, 10-year transplant-free survival remains at 39–50%, with ventricular dysfunction progressing to heart failure (HF) being a com...

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Bibliographic Details
Main Authors: Xinxiu Xu, Jiuann-Huey Ivy Lin, Abha S. Bais, Michael John Reynolds, Tuantuan Tan, George C. Gabriel, Zoie Kondos, Xiaoqin Liu, Sruti S. Shiva, Cecilia W. Lo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
oxygen consumption rate (OCR)
single ventricle congenital heart disease (SV-CHD)
peripheral blood mononuclear cells (PBMC)
heart failure
Fontan
reserve OCR
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.734388/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.734388/full

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