Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction

Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction

Abstract Background AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. The zebrafish genome contains two ambra1 paralogous genes (a...

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Bibliographic Details
Main Authors: Camilla Maria Fontana, Francesca Terrin, Nicola Facchinello, Giacomo Meneghetti, Alberto Dinarello, Lisa Gambarotto, Annalisa Zuccarotto, Micol Caichiolo, Ginevra Brocca, Ranieri Verin, Francesca Nazio, Oliana Carnevali, Francesco Cecconi, Paolo Bonaldo, Luisa Dalla Valle
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Biological Research
Subjects:
Ambra1
PGCs
Sex differentiation
Reproduction
Zebrafish
Mouse
Online Access:https://doi.org/10.1186/s40659-023-00430-9

Internet

https://doi.org/10.1186/s40659-023-00430-9

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