Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

Astrocytic phagocytosis has been shown to play a role in synaptic pruning during development, but whether adult astrocytes possess phagocytic ability is unclear. Here the authors show that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.

Bibliographic Details
Main Authors: Yosuke M. Morizawa, Yuri Hirayama, Nobuhiko Ohno, Shinsuke Shibata, Eiji Shigetomi, Yang Sui, Junichi Nabekura, Koichi Sato, Fumikazu Okajima, Hirohide Takebayashi, Hideyuki Okano, Schuichi Koizumi
Format: Article
Language:English
Published: Nature Portfolio 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00037-1

Internet

https://doi.org/10.1038/s41467-017-00037-1

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