Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
Astrocytic phagocytosis has been shown to play a role in synaptic pruning during development, but whether adult astrocytes possess phagocytic ability is unclear. Here the authors show that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00037-1 |