Effect of apatinib on the pharmacokinetics of tramadol and O-desmethyltramadol in rats
Since the combination of anticancer drugs and opioids is very common, apatinib and tramadol are likely to be used in combination clinically. This study evaluated the effects of apatinib on the pharmacokinetics of tramadol and its main metabolite O-desmethyltramadol in Sprague-Dawley (SD) rats and th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PeerJ Inc.
2023-09-01
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| Series: | PeerJ |
| Subjects: | |
| Online Access: | https://peerj.com/articles/16051.pdf |