Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases

Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases

Abstract Transcription factor IIH (TFIIH) is a protein assembly essential for transcription initiation and nucleotide excision repair (NER). Yet, understanding of the conformational switching underpinning these diverse TFIIH functions remains fragmentary. TFIIH mechanisms critically depend on two tr...

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Bibliographic Details
Main Authors: Jina Yu, Chunli Yan, Thomas Dodd, Chi-Lin Tsai, John A. Tainer, Susan E. Tsutakawa, Ivaylo Ivanov
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38416-6

Internet

https://doi.org/10.1038/s41467-023-38416-6

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