ATF6α contributes to rheumatoid arthritis by inducing inflammatory cytokine production and apoptosis resistance

ATF6α contributes to rheumatoid arthritis by inducing inflammatory cytokine production and apoptosis resistance

ObjectiveThe contribution of activating transcription factor 6α (ATF6α) in rheumatoid arthritis (RA) pathogenesis, especially on fibroblast-like synoviocytes (FLSs), has been suggested by its sensitivity to inflammatory stimulus. However, the exact role and therapeutic potential of ATF6α in RA remai...

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Bibliographic Details
Main Authors: Luna Ge, Ting Wang, Dandan Shi, Yun Geng, Huancai Fan, Ruojia Zhang, Yuang Zhang, Jianli Zhao, Shufeng Li, Yi Li, Haojun Shi, Guanhua Song, Jihong Pan, Lin Wang, Jinxiang Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
unfolded protein response
ATF6α
BIRC3
inflammation
apoptosis resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.965708/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.965708/full

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