Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration

Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration

Cryo-EM structures of Ty1 integrase-Pol III complexes reveal determinants of Ty1 targeting upstream of Pol III-transcribed genes, and a functional impact of the integrase on Pol III activity that may increase the probability of Ty1 integration.

Bibliographic Details
Main Authors: Phong Quoc Nguyen, Sonia Huecas, Amna Asif-Laidin, Adrián Plaza-Pegueroles, Beatrice Capuzzi, Noé Palmic, Christine Conesa, Joël Acker, Juan Reguera, Pascale Lesage, Carlos Fernández-Tornero
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37109-4

Internet

https://doi.org/10.1038/s41467-023-37109-4

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