Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

Members of the SH3- and ankyrin repeat (SHANK) protein family are considered as master scaffolds of the postsynaptic density of glutamatergic synapses. Several missense mutations within the canonical SHANK3 isoform have been proposed as causative for the development of autism spectrum disorders (ASD...

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Bibliographic Details
Main Authors: Michael Bucher, Stephan Niebling, Yuhao Han, Dmitry Molodenskiy, Fatemeh Hassani Nia, Hans-Jürgen Kreienkamp, Dmitri Svergun, Eunjoon Kim, Alla S Kostyukova, Michael R Kreutz, Marina Mikhaylova
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
conformational dynamics
SHANK3
protein folding
postsynaptic density
synaptic protein turnover
autism
Online Access:https://elifesciences.org/articles/66165

Internet

https://elifesciences.org/articles/66165

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