Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals

Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals

Abstract Background Clusterin, also known as apolipoprotein J (apoJ), is one of the most abundantly expressed apolipoproteins in the brain after apolipoprotein E (apoE). Like the ε4 allele of the apolipoprotein E gene (APOE), the clusterin gene (CLU) is a risk locus for Alzheimer’s disease, and may...

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Bibliographic Details
Main Authors: Liv Tybjærg Nordestgaard, Anne Tybjærg-Hansen, Katrine Laura Rasmussen, Børge G. Nordestgaard, Ruth Frikke-Schmidt
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Medicine
Subjects:
Clusterin
Apolipoprotein E
Alzheimer’s disease
Vascular dementia
Ischemic cerebrovascular disease
Ischemic heart disease
Online Access:http://link.springer.com/article/10.1186/s12916-018-1029-3

Internet

http://link.springer.com/article/10.1186/s12916-018-1029-3

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