Dosing Pattern and Early Cumulative Dose of Liposomal Irinotecan in Metastatic Pancreatic Cancer: A Real-World Multicenter Study

Dosing Pattern and Early Cumulative Dose of Liposomal Irinotecan in Metastatic Pancreatic Cancer: A Real-World Multicenter Study

IntroductionThis multicenter, real-world cohort study aimed to evaluate the effectiveness of early cumulative dose administration and dosing pattern of liposomal irinotecan plus fluorouracil/leucovorin (nal-IRI+5-FU/LV) in patients with gemcitabine-refractory metastatic pancreatic ductal adenocarcin...

Full description

Bibliographic Details
Main Authors:	Yung-Yeh Su, Nai-Jung Chiang, Chung-Pin Li, Chia-Jui Yen, Shih-Hung Yang, Wen-Chi Chou, Jen-Shi Chen, Tai-Jan Chiu, Yen-Yang Chen, Shih-Chang Chuang, Li-Yuan Bai, Chang-Fang Chiu, Cheng-Ming Peng, De-Chuan Chan, Sz-Chi Chiu, Yi-Hsin Yang, Yan-Shen Shan, Li‐Tzong Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Oncology
Subjects:	pancreatic cancer nal-IRI dose intensity dose escalation strategy real world
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.800842/full

Similar Items

Real-World Data Validation of NAPOLI-1 Nomogram for the Prediction of Overall Survival in Metastatic Pancreatic Cancer
by: Yung-Yeh Su, et al.
Published: (2023-02-01)

Liposomal irinotecan pre-emptive dose reduction in patients with pancreatic ductal adenocarcinoma: 667 patients’ experience within a population-based study
by: Tai-Jan Chiu, et al.
Published: (2021-11-01)

Modified gemcitabine, S-1, and leucovorin combination for patients with newly diagnosed locally advanced or metastatic pancreatic adenocarcinoma: A multi-center retrospective study in Taiwan.
by: Chia-Yu Chen, et al.
Published: (2020-01-01)

Phase I dose escalation study of sorafenib plus S-1 for advanced solid tumors
by: Hui-Jen Tsai, et al.
Published: (2021-03-01)

Development of Possible Next Line of Systemic Therapies for Gemcitabine-Resistant Biliary Tract Cancers: A Perspective from Clinical Trials
by: Nai-Jung Chiang, et al.
Published: (2021-01-01)

Comparative Effectiveness and Safety of Standard-Dose and Low-Dose Pembrolizumab in Patients with Non-Small-Cell Lung Cancer: A Multi-Institutional Cohort Study in Taiwan
by: Kai-Cheng Chang, et al.
Published: (2022-02-01)

Cardiac radiation dose predicts survival in esophageal squamous cell carcinoma treated by definitive concurrent chemotherapy and intensity modulated radiotherapy
by: Tzu-Hui Pao, et al.
Published: (2020-09-01)

A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway.
by: Nai-Jung Chiang, et al.
Published: (2013-01-01)

Optimization of Photobiomodulation Dose in Biological Tissue by Adjusting the Focal Point of Lens
by: Chuan-Tsung Su, et al.
Published: (2022-05-01)

Germline mutations of homologous recombination genes and clinical outcomes in pancreatic cancer: a multicenter study in Taiwan
by: Siao Muk Cheng, et al.
Published: (2024-02-01)

Rectal Dose Is the Other Dosimetric Factor in Addition to Small Bowel for Prediction of Acute Diarrhea during Postoperative Whole-Pelvic Intensity-Modulated Radiotherapy in Gynecologic Patients
by: Eng-Yen Huang, et al.
Published: (2021-01-01)

Estimation of the Surface Dose in Breast Irradiation by the Beam Incident Angle and the 1 cm Depth Dose
by: Tsung-Yu Yen, et al.
Published: (2022-04-01)

Determination of Low Muscle Mass by Muscle Surface Index of the First Lumbar Vertebra Using Low-Dose Computed Tomography
by: Ping-Huai Wang, et al.
Published: (2022-04-01)

Safety and efficacy of high-dose daptomycin as salvage therapy for severe gram-positive bacterial sepsis in hospitalized adult patients
by: Lai Chung-Chih, et al.
Published: (2013-02-01)

Case Report: High-dose steroid and IVIG successful treatment in a case of COVID-19-associated autoimmune encephalitis: a literature review
by: Chi-Hung Liu, et al.
Published: (2023-09-01)

Comparison of the safety and efficacy of a fixed-dose combination regimen and separate formulations for pulmonary tuberculosis treatment
by: Jiun-Ting Wu, et al.
Published: (2015-06-01)

A software tool for both the maximum tolerated dose and the optimal biological dose finding trials in early phase designs
by: Chen Li, et al.
Published: (2022-12-01)

Divaricoside Exerts Antitumor Effects, in Part, by Modulating Mcl-1 in Human Oral Squamous Cell Carcinoma Cells
by: Jing-Ru Weng, et al.
Published: (2019-01-01)

Cigarette smoking dose as a predictor of need for surgical intervention in patients with lumbar disk herniation
by: Shang-Lin Chiang, et al.
Published: (2014-01-01)

Association between History of Dental Amalgam Fillings and Risk of Parkinson's Disease: A Population-Based Retrospective Cohort Study in Taiwan.
by: Yung-Chuang Hsu, et al.
Published: (2016-01-01)

Dose- and time-dependent renoprotection of Angelica sinensis in patients with chronic kidney disease: A longitudinal cohort study
by: Hsiao-Tien Chen, et al.
Published: (2023-04-01)

Low-dose nivolumab in advanced hepatocellular carcinoma
by: Yen-Hao Chen, et al.
Published: (2022-11-01)

Effects of low-dose computed tomography on lung cancer screening: a systematic review, meta-analysis, and trial sequential analysis
by: Kai-Lin Huang, et al.
Published: (2019-07-01)

A practical approach to estimating optic disc dose and macula dose without treatment planning in ocular brachytherapy using 125I COMS plaques
by: Yongsook C. Lee, et al.
Published: (2018-11-01)

Post-fire performance evaluation of steel connections under a column-loss scenario
by: Heui-Yung Chang, et al.
Published: (2024-04-01)

Development of CT Effective Dose Conversion Factors from Clinical CT Examinations in the Republic of Korea
by: Sang-Kyung Lee, et al.
Published: (2020-09-01)

Integrating 18F‐FDG PET/CT with lung dose‐volume for assessing lung inflammatory changes after arc‐based radiotherapy for esophageal cancer: A pilot study
by: Chen‐Xiong Hsu, et al.
Published: (2022-11-01)

Reappraisal of therapeutic vancomycin trough concentrations with empirical dosing in neonatal infections
by: Tzung-Yi Lee, et al.
Published: (2023-03-01)

Evaluation of dosing strategy for pembrolizumab for oncology indications
by: Tomoko Freshwater, et al.
Published: (2017-05-01)

Excess mortality and long-term disability from healthcare-associated carbapenem-resistant Acinetobacter baumannii infections: A nationwide population-based matched cohort study.
by: Chiu-Hsia Su, et al.
Published: (2023-01-01)

Excess mortality and long-term disability from healthcare-associated carbapenem-resistant Acinetobacter baumannii infections: A nationwide population-based matched cohort study
by: Chiu-Hsia Su, et al.
Published: (2023-01-01)

Boosting with Multiple Doses of mRNA Vaccine after Priming with Two Doses of Protein Subunit Vaccine MVC-COV1901 Elicited Robust Humoral and Cellular Immune Responses against Emerging SARS-CoV-2 Variants
by: Chun-Hsiang Chiu, et al.
Published: (2022-10-01)

Population Pharmacokinetics and Dose Optimization of Ganciclovir in Critically Ill Children
by: SiChan Li, et al.
Published: (2021-01-01)

Effect of Multi-Dose Dispensing on Medication Regimen Complexity: A Real-World Study
by: Sunmin Lee, et al.
Published: (2024-02-01)

FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism
by: Li-Yuan Bai, et al.
Published: (2017-07-01)

Regorafenib plus FOLFIRI with irinotecan dose escalated according to uridine diphosphate glucuronosyltransferase 1A1genotyping in previous treated metastatic colorectal cancer patients:study protocol for a randomized controlled trial
by: Cheng-Jen Ma, et al.
Published: (2019-12-01)

Skin Surface Dose for Whole Breast Radiotherapy Using Personalized Breast Holder: Comparison with Various Radiotherapy Techniques and Clinical Experiences
by: Chiu-Ping Chen, et al.
Published: (2022-06-01)

Performance characteristics of an independent dose verification program for helical tomotherapy
by: Isaac C. F. Chang, et al.
Published: (2017-01-01)

Clinical evaluation for the difference of absorbed doses calculated to medium and calculated to water by Monte Carlo method
by: Li Chen, et al.
Published: (2018-07-01)

A Dosimetric Analysis of Reduction Cardiac Dose with Lead Shielding in Breast Cancer Radiotherapy
by: Hsiao-Wen Chiu, et al.
Published: (2021-10-01)