Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody

Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody

Targeting CD19 represents a promising strategy for the therapy of B-cell malignancies. Although non-engineered CD19 antibodies are poorly effective in mediating complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC) or antibody-dependent cellular phagocytosis (...

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Bibliographic Details
Main Authors: Carina Lynn Gehlert, Pegah Rahmati, Ammelie Svea Boje, Dorothee Winterberg, Steffen Krohn, Thomas Theocharis, Elisa Cappuzzello, Anja Lux, Falk Nimmerjahn, Ralf J. Ludwig, Marta Lustig, Thies Rösner, Thomas Valerius, Denis Martin Schewe, Christian Kellner, Katja Klausz, Matthias Peipp
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
antibody therapy
Fc engineering
CD19
antibody hexamerization
CDC
ADCC
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.957874/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.957874/full

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