CD40 agonist-induced IL-12p40 potentiates hepatotoxicity

CD40 agonist-induced IL-12p40 potentiates hepatotoxicity

Background CD40 is a compelling target for cancer immunotherapy, however, attempts to successfully target this pathway have consistently been hampered by dose-limiting toxicity issues in the clinic that prevents the administration of efficacious doses.Methods Here, using cytokine and cytokine recept...

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Bibliographic Details
Main Authors: Wei Chen, Yan Qu, Shahram Salek-Ardakani, Graham Thomas, Jonathan Heyen, Javier Chaparro-Riggers, Caroline Bonnans, Wenqian He, Bernard Buetow, Min Liao, Breanna Jung, Smitha Pillai, Diane Matsumoto
Format: Article
Language:English
Published: BMJ Publishing Group 2020-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/8/1/e000624.full

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https://jitc.bmj.com/content/8/1/e000624.full

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