Enhancing Oral Bioavailability and Brain Biodistribution of Perillyl Alcohol Using Nanostructured Lipid Carriers

Enhancing Oral Bioavailability and Brain Biodistribution of Perillyl Alcohol Using Nanostructured Lipid Carriers

Perillyl alcohol (POH), a bioactive monoterpenoid derived from limonene, shows promise as an antitumor agent for brain tumor treatment. However, its limited oral bioavailability and inadequate brain distribution hinder its efficacy. To address these challenges, this study developed nanostructured li...

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Bibliographic Details
Main Authors: Samila Horst Peczek, Ana Paula Santos Tartari, Isabella Camargo Zittlau, Camila Diedrich, Christiane Schineider Machado, Rubiana Mara Mainardes
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceuticals
Subjects:
lipid nanoparticles
perillyl acid
pharmacokinetics
biodistribution
Online Access:https://www.mdpi.com/1424-8247/16/8/1055

Internet

https://www.mdpi.com/1424-8247/16/8/1055

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