Synthesis, anticancer and molecular docking studies of new class of benzoisoxazolyl-piperidinyl-1, 2, 3-triazoles

Synthesis, anticancer and molecular docking studies of new class of benzoisoxazolyl-piperidinyl-1, 2, 3-triazoles

A small library of hitherto unexplored novel 5-fluorobenzoisoxazolyl-piperidinyl-1, 2, 3-triazole derivatives has been synthesized from 2-azido-fluorobenzoisoxazolyl piperidinyl ethanone and various alkynes in good to excellent yields through a click chemistry approach. Compounds thus synthesized we...

Full description

Bibliographic Details
Main Authors:	Govindhan Muniyappan, Subramanian Kathavarayan, Chandrasekar Balachandran, Easwaramoorthi Kalliyappan, Sakkarapalayam M. Mahalingam, Abdul Ajees Abdul Salam, Shin Aoki, Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar
Format:	Article
Language:	English
Published:	Elsevier 2020-12-01
Series:	Journal of King Saud University: Science
Subjects:	1,2,3-Triazoles Click chemistry reaction Anticancer activity Molecular docking studies
Online Access:	http://www.sciencedirect.com/science/article/pii/S1018364720302809

Similar Items

A novel class of 1,4-disubstituted 1,2,3-triazoles: Regioselective synthesis, antimicrobial activity and molecular docking studies
by: Chennakesava Rao Kella, et al.
Published: (2020-12-01)

Regioselective synthesis and antioxidant activity of a novel class of mono and C2-symmetric bis-1,2,3-triazole and acridinedione grafted macromolecules
by: Rajesh Raju, et al.
Published: (2020-12-01)

A New Class of β–Pyrrolidino-1,2,3-Triazole Derivatives as β-Adrenergic Receptor Inhibitors: Synthesis, Pharmacological, and Docking Studies
by: Kaliyappan Easwaramoorthi, et al.
Published: (2019-09-01)

Design, Synthesis, and Antimicrobial Activities of 1,2,3-Triazole Glycoside Clickamers
by: Tamer El Malah, et al.
Published: (2020-02-01)

Green ultrasound-assisted three-component click synthesis of novel 1H-1,2,3-triazole carrying benzothiazoles and fluorinated-1,2,4-triazole conjugates and their antimicrobial evaluation
by: Rezki Nadjet, et al.
Published: (2017-09-01)

Pyridinyl-triazole ligand systems for highly efficient CuI-catalyzed azide-alkyne cycloaddition
by: Lei Zheng, et al.
Published: (2021-01-01)

Synthesis of novel pyrazoline based bis (1,2,3-triazole) scaffolds via click chemistry
by: Kiran Kothuri, et al.
Published: (2017-01-01)

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry
by: Daniela Pereira, et al.
Published: (2021-12-01)

1,2,3-Triazoles as Amide-bond Surrogates in Peptidomimetics
by: Ibai E. Valverde, et al.
Published: (2013-04-01)

Triazole-Modified Nucleic Acids for the Application in Bioorganic and Medicinal Chemistry
by: Dagmara Baraniak, et al.
Published: (2021-05-01)

Synthesis of New Zinc and Copper Coordination Polymers Derived from Bis (Triazole) Ligands
by: Maria Cristina Al-Matarneh, et al.
Published: (2024-01-01)

Recent Progress in Catalytic Synthesis of 1,2,3-Triazoles
by: Antonio De Nino, et al.
Published: (2021-09-01)

Synthesis of Novel Glycerol-Derived 1,2,3-Triazoles and Evaluation of Their Fungicide, Phytotoxic and Cytotoxic Activities
by: Adilson Vidal Costa, et al.
Published: (2017-10-01)

Synthesis of 4-Arylselanyl-1<i>H</i>-1,2,3-triazoles from Selenium-Containing Carbinols
by: Francesca Begini, et al.
Published: (2021-04-01)

1,2,3-Triazoles as Biomimetics in Peptide Science
by: Naima Agouram, et al.
Published: (2021-05-01)

Click Triazole as a Linker for Pretargeting Strategies: Synthesis, Docking Investigations, Fluorescence Diagnosis, and Antibacterial Action Studies
by: Qian Liu, et al.
Published: (2023-03-01)

Regioselective synthesis, characterization and antimicrobial evaluation of amide-ether linked 1,4-disubstituted 1,2,3-triazoles
by: Kaushik Chander Prakash, et al.
Published: (2017-01-01)

Molecular Hybridization of Alkaloids Using 1,2,3-Triazole-Based Click Chemistry
by: Devan Buchanan, et al.
Published: (2023-11-01)

Natural Benzo/Acetophenones as Leads for New Synthetic Acetophenone Hybrids Containing a 1,2,3-Triazole Ring as Potential Antifouling Agents
by: Ana Rita Neves, et al.
Published: (2021-11-01)

Design and Synthesis of Novel Imidazole Derivatives Possessing Triazole Pharmacophore with Potent Anticancer Activity, and In Silico ADMET with GSK-3β Molecular Docking Investigations
by: Fawzia Al-blewi, et al.
Published: (2021-01-01)

Efficient One-Pot Synthesis of Triazole-Linked Morpholinone Scaffolds by CuAAC in the Presence of 18-Crown-6
by: A. Mayooufi, et al.
Published: (2018-10-01)

Regioselective Synthesis and Molecular Docking Studies of 1,5-Disubstituted 1,2,3-Triazole Derivatives of Pyrimidine Nucleobases
by: Vincenzo Algieri, et al.
Published: (2022-12-01)

Design, Modeling and Synthesis of 1,2,3-Triazole-Linked Nucleoside-Amino Acid Conjugates as Potential Antibacterial Agents
by: Sarah N. Malkowski, et al.
Published: (2017-10-01)

Diethyl (2-(4-Phenyl-1<i>H</i>-1,2,3-triazol-1-yl)benzyl) Phosphate
by: Gabriel P. da Costa, et al.
Published: (2021-06-01)

An Overview on the Performance of 1,2,3-Triazole Derivatives as Corrosion Inhibitors for Metal Surfaces
by: Meryem Hrimla, et al.
Published: (2021-12-01)

Design, synthesis, in silico and in vitro antimicrobial screenings of novel 1,2,4-triazoles carrying 1,2,3-triazole scaffold with lipophilic side chain tether
by: Mohamed Reda Aouad, et al.
Published: (2017-11-01)

Synthesis of Dense 1,2,3-Triazole Oligomers Consisting Preferentially of 1,5-Disubstituted Units via Ruthenium(II)-Catalyzed Azide–Alkyne Cycloaddition
by: Ryoichi Taguchi, et al.
Published: (2023-05-01)

The fate of heterogeneous catalysis & click chemistry for 1,2,3-triazoles: Nobel prize in chemistry 2022
by: Vijay Kumar, et al.
Published: (2023-03-01)

Novel 1,2,3-Triazole-Based Benzothiazole Derivatives: Efficient Synthesis, DFT, Molecular Docking, and ADMET Studies
by: Zohreh Mirjafary, et al.
Published: (2022-12-01)

Supported Tris-Triazole Ligands for Batch and Continuous-Flow Copper-Catalyzed Huisgen 1,3-Dipolar Cycloaddition Reactions
by: Alessandra Pucci, et al.
Published: (2020-04-01)

Synthesis, Spectroscopic and Theoretical Studies of New Quasi-Podands from Bile Acid Derivatives Linked by 1,2,3-Triazole Rings
by: Tomasz Pospieszny, et al.
Published: (2014-02-01)

New 1,2,3-Triazole-Containing Hybrids as Antitumor Candidates: Design, Click Reaction Synthesis, DFT Calculations, and Molecular Docking Study
by: Islam H. El Azab, et al.
Published: (2021-01-01)

CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview
by: Dileep Kumar Singh
Published: (2023-03-01)

Copper(I)-catalyzed tandem reaction: synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes
by: Muhammad Israr, et al.
Published: (2018-11-01)

Regioselective synthesis of 1,2,3-triazoles catalyzed over ZnO supported copper oxide nanocatalyst as a new and efficient recyclable catalyst in water
by: Jalal Albadi, et al.
Published: (2015-07-01)

1,2,3-Triazoles: Controlled Switches in Logic Gate Applications
by: Debanjana Ghosh, et al.
Published: (2023-08-01)

Synthesis of (1,2,3-triazol-4-yl)methyl Phosphinates and (1,2,3-Triazol-4-yl)methyl Phosphates by Copper-Catalyzed Azide-Alkyne Cycloaddition
by: Anna Tripolszky, et al.
Published: (2019-05-01)

Semi-synthesis of β-keto-1,2,3-triazole derivatives from ethinylestradiol and evaluation of the cytotoxic activity
by: Thayane M. Queiroz, et al.
Published: (2019-09-01)

Triazole-Modified Peptidomimetics: An Opportunity for Drug Discovery and Development
by: Agnieszka Staśkiewicz, et al.
Published: (2021-05-01)

Biological importance and synthesis of 1,2,3-triazole derivatives: a review
by: Mira J. Vaishnani, et al.
Published: (2024-12-01)