Gut bacterial metabolite Urolithin A inhibits myocardial fibrosis through activation of Nrf2 pathway in vitro and in vivo

Gut bacterial metabolite Urolithin A inhibits myocardial fibrosis through activation of Nrf2 pathway in vitro and in vivo

Abstract Background Myocardial fibrosis after myocardial infarction (MI) is one of the leading causes of cardiovascular diseases. Cardiac fibroblasts (CFs) are activated and promoted by MI to undergo myofibroblast transformation (CMT). Urolithin A (UA) is an active and effective gut metabolite deriv...

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Bibliographic Details
Main Authors: Pengfei Chen, Junyu Pei, Xiaopu Wang, Shi Tai, Liang Tang, Xinqun Hu
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Molecular Medicine
Subjects:
Myocardial fibrosis
Urolithin A
Myofibroblast transformation
Nrf2
Online Access:https://doi.org/10.1186/s10020-022-00444-1

Internet

https://doi.org/10.1186/s10020-022-00444-1

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