Hybridization of the effective pharmacophores for treatment of epilepsy: design, synthesis, in vivo anticonvulsant activity, and in silico studies of phenoxyphenyl-1,3,4-oxadiazole-thio-N-phenylacetamid hybrids

Hybridization of the effective pharmacophores for treatment of epilepsy: design, synthesis, in vivo anticonvulsant activity, and in silico studies of phenoxyphenyl-1,3,4-oxadiazole-thio-N-phenylacetamid hybrids

Abstract Background Epilepsy is a common neurological disorder. The available drugs for this disease only control convulsions in nearly 70% of patients, while bearing many side effects. In this study, a new series of phenoxyphenyl-1,3,4-oxadiazole-thio-N-phenylacetamid hybrids 8a-m was designed, syn...

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Bibliographic Details
Main Authors: Azadeh Fakhrioliaei, Fahimeh Abedinifar, Pedram Salehi Darjani, Maryam Mohammadi-Khanaposhtani, Bagher Larijani, Nematollah Ahangar, Mohammad Mahdavi
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Chemistry
Subjects:
Anticonvulsant
1,3,4-Oxadiazole
Phenoxyphenyl
Thio-N-phenylacetamid
Online Access:https://doi.org/10.1186/s13065-023-01000-6

Internet

https://doi.org/10.1186/s13065-023-01000-6

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