The prognostic significance of CXCR4 and SDF-1 in differentiated thyroid cancer depends on CD8+ density

The prognostic significance of CXCR4 and SDF-1 in differentiated thyroid cancer depends on CD8+ density

Abstract Background Tumor infiltration with cytotoxic CD8+ T-cells is associated with a favorable outcome in several neoplasms, including thyroid cancer. The chemokine axis CXCR4/SDF-1 correlates with more aggressive tumors, but little is known concerning the prognostic relevance in relation to the...

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Bibliographic Details
Main Authors: Alexander Wilhelm, Isabelle Lemmenmeier, Alexandros Lalos, Alberto Posabella, Venkatesh Kancherla, Salvatore Piscuoglio, Tarik Delko, Markus von Flüe, Kathrin Glatz, Raoul André Droeser
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Endocrine Disorders
Subjects:
Differentiated thyroid cancer
Tumor microenvironment
Chemokines
CXCR4
SDF-1
CD8
Online Access:https://doi.org/10.1186/s12902-022-01204-2

Internet

https://doi.org/10.1186/s12902-022-01204-2

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