Clinical trial simulation to evaluate tenofovir disoproxil fumarate/emtricitabine HIV pre-exposure prophylaxis dosing during pregnancy

Clinical trial simulation to evaluate tenofovir disoproxil fumarate/emtricitabine HIV pre-exposure prophylaxis dosing during pregnancy

ObjectiveTo evaluate upward-adjustment of tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) pre-exposure prophylaxis (PrEP) dosing during pregnancy in order to maintain target plasma concentrations associated with HIV protection.DesignPopulation pharmacokinetic (PK) modeling and clinical trial...

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Bibliographic Details
Main Authors: Rachel K. Scott, Yifan Yu, Mark A. Marzinke, Jenell S. Coleman, Craig W. Hendrix, Robert Bies
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Reproductive Health
Subjects:
pregnancy
pre-exposure prophylaxis
HIV infection
tenofovir
emtricitabine
clinical trial simulation
Online Access:https://www.frontiersin.org/articles/10.3389/frph.2023.1224580/full

Internet

https://www.frontiersin.org/articles/10.3389/frph.2023.1224580/full

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