Antiseizure and Neuroprotective Efficacy of Midazolam in Comparison with Tezampanel (LY293558) against Soman-Induced Status Epilepticus

Antiseizure and Neuroprotective Efficacy of Midazolam in Comparison with Tezampanel (LY293558) against Soman-Induced Status Epilepticus

Acute exposure to nerve agents induces status epilepticus (SE), which can cause death or long-term brain damage. Diazepam is approved by the FDA for the treatment of nerve agent-induced SE, and midazolam (MDZ) is currently under consideration to replace diazepam. However, animal studies have raised...

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Bibliographic Details
Main Authors: Taiza H. Figueiredo, Vassiliki Aroniadou-Anderjaska, Volodymyr I. Pidoplichko, James P. Apland, Maria F. M. Braga
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Toxics
Subjects:
soman
seizures
neuroprotection
amygdala
midazolam
tezampanel
Online Access:https://www.mdpi.com/2305-6304/10/8/409

Internet

https://www.mdpi.com/2305-6304/10/8/409

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