PU-H71 (NSC 750424): a molecular masterpiece that targets HSP90 in cancer and beyond

PU-H71 (NSC 750424): a molecular masterpiece that targets HSP90 in cancer and beyond

Heat shock protein 90 (HSP90) is a pivotal molecular chaperone with multifaceted roles in cellular health and disease. Herein, we explore how HSP90 orchestrates cellular stress responses, particularly through its partnership with heat shock factor 1 (HSF-1). PU-H71, a selective inhibitor of HSP90, d...

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Bibliographic Details
Main Authors: Sameh Saber, Rasha Abdelhady, Mai A. Elhemely, Elsayed A. Elmorsy, Rabab S. Hamad, Mustafa Ahmed Abdel-Reheim, Attalla F. El-kott, Mohammed A. AlShehri, Kareem Morsy, Ali S. AlSheri, Mahmoud E. Youssef
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
Hsp90
PU-H71 (NSC 750424)
tumorigenesis
apoptosis
oncogenic signals
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1475998/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1475998/full

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