Topical and systemic GLP-1R agonist administration both rescue retinal ganglion cells in hypertensive glaucoma

Topical and systemic GLP-1R agonist administration both rescue retinal ganglion cells in hypertensive glaucoma

Glaucomatous neurodegeneration, a blinding disease affecting millions worldwide, has a need for the exploration of new and effective therapies. Previously, the glucagon-like peptide-1 receptor (GLP-1R) agonist NLY01 was shown to reduce microglia/macrophage activation, rescuing retinal ganglion cells...

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Bibliographic Details
Main Authors: Emily C. N. Lawrence, Michelle Guo, Turner D. Schwartz, Jie Wu, Jingwen Lu, Sergei Nikonov, Jacob K. Sterling, Qi N. Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
glaucoma
neuroprotection
glucagon-like peptide-1 receptor agonist
retinal ganglion cell (RGC)
optic nerve (ON)
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1156829/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1156829/full

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